課程名稱: 細胞微機電及微流體導論 (Introduction to Cellular BioMEMS and Biomicrofluidics) 1.Cellular biomechanics: anatomy and physiology of cells, mechanics of cytoskeleton, cell-matrix interaction, focal adhesions, mechanical model, mechanoreceptors, mechanical behavior of cells: mitosis, migration, and introduction to infection induced cell abnormality. 2.Tissue Engineering: microcirculation, capillary anatomy, diffusion and convection, Starling law, osmotic pressure, interstitial flow, basics of angiogenesis and vasculogenesis. 3.BioMEMS: Photolithography, bulk micromachining, surface micromachining, micro-molding, plastic manufacturing. 4.Microfluidics: scaling laws, surface to volume ratio, hydraulic resistance, wall shear stress, diffusion, capillary flow, hydrodynamics in porous media. 5.Special topic: Cell-based chip for biotechnology - bioreactors, studies of mechanics of abnormal cells, cell sorting, cell trapping. 6.Special topic: BioMEMS for cell biology - substrate dependency of cells, cell-cell contact, cell migration. 7.Special topic: Tissue microengineering - 3D culture, angiogenesis, vasculogenesis, organ on a chip.

(1) Introduce how to use basic mechanics to explain cell and tissue mechanics. (2) Explain how to apply cell mechanics to the design of BioMEMS and Biomicrofluidic devices (3) Understand the applications of BioMEMS and Biomicrofluidics in medical applications

待補

Major Reference textbook: Introduction to BioMEMS, Albert Folch, CRC Press; 1st ed. (August 21, 2012) Ch1 How do we make small things? Ch2 Micropatterning of substrates and cells Ch3 Microfluidics Ch5 Cell-based chips for biotechnology Ch6 BioMEMS for cell biology Ch7 Tissue microengineering Other Reference book：Essential Cell Biology, Bruce Albert, et al. Garland Science, 2nd ed. (September 25, 2003) Ch17 Cytoskeleton Ch19 Cell division Introductory Biomechanics - From Cells to Organisms, C. Ross Ethier and Craig A. Simmons, Cambridge University Press (April 9, 2007) Ch2 Cellular biomechanics Ch3 Hemodynamics Ch4 The circulatory system Ch5 Interstitial fluid flow Fundamental of Microfabrication, Marc Madou, CRC Press Ch1 Lithography Ch2 Pattern transfer with dry etching technologies Ch4 Wet bulk micromachining Ch5 Surface micromachining. Theoretical Microfluidics, HenrikBruus, Oxford University Press, (Nov 17, 2007) Ch2 Governing equations Ch3 Basic flow solutions Ch4 Hydraulic resistance and compliance Ch5 Diffusion